If I have a large number of Always conditions, is it better to have them all run within 1 trigger or to split them up into several triggers?
My aim is for speed and efficiency of trigger operations.

It makes no difference.

It'll be a bit faster if you put all of them in the same trigger. But the difference is so small that you won't ever notice. Do not care about this stuff until you actually have lag problems (and that means having thousands and thousands of triggers).

Mainly, do what you find most organized.. for me, this is putting it all in the same trigger, since I know where to go if an always condition isn't working. But yes, it makes no practical difference in performance.